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TGFBRAP1 antibody

CAT: 0710-FNab08646Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab08646Size:100 µg
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Background
Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2. Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25266290) . Functions predominantly in APPL1-containing endosomes and in degradative but not recycling trafficking of endocytosed cargo (PubMed:25266290) .
Synonyms
Transforming growth factor-beta receptor-associated protein 1 (TGF-beta receptor-associated protein 1, TRAP-1, TRAP1) |TGFBRAP1
Gene ID
9392
UniProt
Q8WUH2
Host
Rabbit
Reactivity
Human
Immunogen
Transforming growth factor, beta receptor associated protein 1
Target
TGFBRAP1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
80 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF

UniProtKB · Q8WUH2

Transforming growth factor-beta receptor-associated protein 1

TGFA1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8WUH2
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TGFBRAP1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
TGF-beta receptor-associated protein 1, TRAP-1, TRAP1
EC number
—
Processing
—
Secondary accessions
A8K5R7, D3DVJ8, O60466
Protein keywords

Cellular component

CytoplasmEndosome

Biological process

Protein transportTransport

Technical term

Proteomics identificationReference proteome

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