TGFB1 antibody
CAT:
710-FNab08638
Size:
100 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
TGFB1 antibody
- Background: TGFB, also named as LAP and TGFB1, is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for it. TGFB positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. It is highly expressed in bone. Mutation of TGFB are the cause of Camurati-Engelmann disease(CED) which known as progressive diaphyseal dysplasia 1(DPD1).
- Synonyms: Transforming growth factor beta-1 proprotein|Latency-associated peptide (LAP)|Transforming growth factor beta-1 (TGF-beta-1)|TGFB1|TGFB
- CAS Number: 9007-83-4
- Gene ID: 7040
- UniProt: P01137
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Immunogen: transforming growth factor, beta 1
- Target: TGFB1
- Clonality: Polyclonal
- Isotype: IgG
- Applications: ELISA, WB, IHC
- Field of Research: Signal Transduction, Cardiovascular, Immunology, Developmental biology, Neuroscience, Stem Cells
- Purification: Immunogen affinity purified
- Dilution: WB: 1:200-1:2000; IHC: 1:50-1:500
- Purity: ≥95% as determined by SDS-PAGE
- Form: Liquid
- Molecular Weight: 44 kDa
- Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)