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TFAM antibody

CAT: 0710-FNab08615Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab08615Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.
Synonyms
Transcription factor A, mitochondrial (mtTFA) |Mitochondrial transcription factor 1 (MtTF1) |Transcription factor 6 (TCF-6) |Transcription factor 6-like 2|TFAM|TCF6|TCF6L2
Gene ID
7019
UniProt
Q00059
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Transcription factor A, mitochondrial
Target
TFAM
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP
Field of Research
Neuroscience, Cardiovascular, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:3000; IP: 1:500-1:1000; IHC: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
25 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IP
Immunogen Sequence
1-246aa

UniProtKB · Q00059

Transcription factor A, mitochondrial

TFAM_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q00059
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TFAM
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
mtTFA
EC number
—
Processing
Precursor
Secondary accessions
A8MRB2, A9QXC6, B5BU05, Q5U0C6
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Molecular function

ActivatorDNA-binding

Coding sequence diversity

Alternative splicing

Disease

Disease variantPrimary mitochondrial disease

Cellular component

MitochondrionMitochondrion nucleoid

PTM

Phosphoprotein

Domain

RepeatTransit peptide

Biological process

TranscriptionTranscription regulation

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