TEAD4 antibody

• Background:

  Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.

• Synonyms:

  Transcriptional enhancer factor TEF-3|TEA domain family member 4 (TEAD-4) |Transcription factor 13-like 1|Transcription factor RTEF-1|TEAD4|RTEF1|TCF13L1|TEF3

• Gene ID:

  7004

• UniProt:

  Q15561

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  TEA domain family member 4

• Target:

  TEAD4

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, IP, WB

• Field of Research:

  Cardiovascular, Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:2000; IP: 1:200-1:1000

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  50-55 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, IP, WB