TEAD4 antibody

CAT: 0710-FNab08584Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab08584Size:100 µg
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Background
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.
Synonyms
Transcriptional enhancer factor TEF-3|TEA domain family member 4 (TEAD-4) |Transcription factor 13-like 1|Transcription factor RTEF-1|TEAD4|RTEF1|TCF13L1|TEF3
Gene ID
7004
UniProt
Q15561
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
TEA domain family member 4
Target
TEAD4
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IP, WB
Field of Research
Cardiovascular, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:1000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
50-55 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IP, WB

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