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TCF7 antibody

CAT: 0710-FNab08554Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab08554Size:100 µg
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Background
Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4 (+) CD8 (+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.
Synonyms
Transcription factor 7 (TCF-7) |T-cell-specific transcription factor 1 (T-cell factor 1, TCF-1) |TCF7|TCF1
Gene ID
6932
UniProt
P36402
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Transcription factor 7 (T-cell specific, HMG-box)
Target
TCF7
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Epigenetics, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
43-58 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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