TBCD antibody

CAT: 0710-FNab08519Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab08519Size:100 µg
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Background
Tubulin-folding protein; involved in the first step of the tubulin folding pathway. Modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB) . Acts as a GTPase-activating protein (GAP) for ARL2. Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane.
Synonyms
Tubulin-specific chaperone D|Beta-tubulin cofactor D (tfcD) |SSD-1|Tubulin-folding cofactor D|TBCD|KIAA0988|SSD1|TFCD
Gene ID
6904
UniProt
Q9BTW9
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Tubulin folding cofactor D
Target
TBCD
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IP
Field of Research
Cell Division and Proliferation, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
130 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IP

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