TAP1 antibody

CAT: 0710-FNab08499Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab08499Size:100 µg
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Background
Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.
Synonyms
Antigen peptide transporter 1 (APT1) |ATP-binding cassette sub-family B member 2|Peptide supply factor 1|Peptide transporter PSF1 (PSF-1) |Peptide transporter TAP1|Peptide transporter involved in antigen processing 1|Really interesting new gene 4 protein (RING4) |TAP1|ABCB2|PSF1|RING4|Y3
Gene ID
6890
UniProt
Q03518
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Target
TAP1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IF, WB, IHC, IP
Field of Research
Immunology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
70-81 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IF, WB, IHC, IP

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