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SYT1 antibody

CAT: 0710-FNab08425Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab08425Size:100 µg
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Background
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca (2+) sensors in the process of vesicular trafficking and exocytosis (PMID: 8058779) . SYT1 (synaptotagmin I) was firstly identified as a 65-kDa protein with a wide distribution in neuronal and neurosecretory tissue (PMID: 7298720) . Calcium binding to SYT1 participates in triggering neurotransmitter release at the synapse (PMID: 11242035) . In addition to regulating exocytosis, SYT1 has also been implicated in endocytosis and neurite outgrowth (PMID: 15492212; 11078930; 10336114) . This antibody recognizes endogenous SYT1, which has an experimentally determined molecular mass of 65-68 kDa. An additional band of 47 kDa could also be detected, which is corresponding to the calculated molecular weight of SYT1.
Synonyms
Synaptotagmin-1|Synaptotagmin I (SytI) |p65|SYT1|SVP65|SYT
UniProt
P21579
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synaptotagmin I
Target
SYT1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP
Field of Research
Neuroscience
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:1000; IP: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
65 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IP

UniProtKB · P21579

Synaptotagmin-1

SYT1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P21579
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SYT1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q6AI31
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Ligand

CalciumMetal-binding

Cellular component

CytoplasmCytoplasmic vesicleMembraneSynapse

Biological process

Differentiation

Disease

Disease variant

PTM

GlycoproteinLipoproteinPalmitatePhosphoprotein

Domain

RepeatTransmembraneTransmembrane helix

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