STAT3 antibody

STAT3 antibody

• Background: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene(PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6(IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1(PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation(By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation(PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. This antibody is a mouse monoclonal antibody raised against residues near the N terminus of human STAT3.
• Synonyms: Signal transducer and activator of transcription 3|Acute-phase response factor|STAT3|APRF
• CAS Number: 9007-83-4
• Gene ID: 6774
• UniProt: P40763
• Host: Mouse
• Reactivity: Human, Mouse, Rat
• Immunogen: signal transducer and activator of transcription 3(acute-phase response factor)
• Target: STAT3
• Clonality: Monoclonal
• Isotype: IgG2a
• Clone: 6A9
• Applications: ELISA, WB, IHC, IF, IP
• Field of Research: Epigenetics, Signal Transduction, Metabolism, Cardiovascular, Immunology, Cancer, Developmental biology, Stem Cells
• Purification: Protein A+G purification
• Dilution: WB: 1:2000-1:20000; IP: 1:1000-1:10000; IHC: 1:50-1:500; IF: 1:50-1:500
• Purity: ≥95% as determined by SDS-PAGE
• Form: Liquid
• Molecular Weight: 88 kDa
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)