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SSTR2 antibody

CAT: 0710-FNab08253Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab08253Size:100 µg
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Background
Receptor for somatostatin-14 and-28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha-and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.
Synonyms
Somatostatin receptor type 2 (SS-2-R, SS2-R, SS2R, SST2) |SRIF-1|SSTR2
Gene ID
6752
UniProt
P30874
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Somatostatin receptor 2
Target
SSTR2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, WB
Field of Research
Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:1000; IHC: 1:50-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
41 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, WB

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