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SREBF1 antibody

CAT: 0710-FNab08220Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab08220Size:100 µg
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Background
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity) . Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') . Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') .
Synonyms
Sterol regulatory element-binding protein 1 (SREBP-1) |Class D basic helix-loop-helix protein 1 (bHLHd1) |Sterol regulatory element-binding transcription factor 1|Processed sterol regulatory element-binding protein 1 Alternative names: Transcription factor SREBF1|SREBF1|BHLHD1|SREBP1
Gene ID
6720
UniProt
P36956
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Sterol regulatory element binding transcription factor 1
Target
SREBF1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IP
Field of Research
Neuroscience, Cardiovascular, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
125 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IP

UniProtKB · P36956

Sterol regulatory element-binding protein 1

SRBP1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P36956
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SREBF1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
SREBP-1
EC number
—
Processing
—
Secondary accessions
B0I4X3, B0I4X4, D3DXC4, Q16062, Q59F52, Q6P4R7, Q6PFW7, Q6PJ36, Q8TAK9
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Molecular function

ActivatorDNA-binding

Coding sequence diversity

Alternative splicing

Biological process

Cholesterol metabolismLipid metabolismSteroid metabolismSterol metabolismTranscriptionTranscription regulation

Cellular component

Cytoplasmic vesicleEndoplasmic reticulumGolgi apparatusMembraneNucleus

Disease

Disease variantIchthyosis

PTM

PhosphoproteinUbl conjugation

Domain

TransmembraneTransmembrane helix

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