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SOD1 antibody

CAT: 0710-FNab08103Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab08103Size:100 µg
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Background
Superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult) ) (SOD1, synonyms: ALS, SOD, ALS1, IPOA) binds copper and zinc ions and is one of two isozymes responsible for destroying free uperoxide radicals in the body. This isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis.
Synonyms
Superoxide dismutase [Cu-Zn]|Superoxide dismutase 1 (hSod1) |SOD1
Gene ID
6647
UniProt
P00441
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Superoxide dismutase 1, soluble
Target
SOD1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP, IF
Field of Research
Neuroscience, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IP: 1:500-1:5000; IHC: 1:100-1:400; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
16 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IP, IF
Immunogen Sequence
Full length

UniProtKB · P00441

Superoxide dismutase [Cu-Zn]

SODC_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P00441
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SOD1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
1.15.1.1, 1.8.-.-
Processing
—
Secondary accessions
A6NHJ0, D3DSE4, Q16669, Q16711, Q16838, Q16839, Q16840, Q6NR85
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationDisulfide bondLipoproteinPalmitatePhosphoproteinUbl conjugation

Disease

Amyotrophic lateral sclerosisDisease variantNeurodegeneration

Molecular function

AntioxidantOxidoreductase

Ligand

CopperMetal-bindingZinc

Cellular component

CytoplasmNucleus

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