SNX6 antibody

Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable) . Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774) . The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable) . Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988) . Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574) . May function as link between transport vesicles and dynactin (Probable) . Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142) . Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942) . In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity) . May contribute to transcription regulation (Probable) .

Sorting nexin-6|TRAF4-associated factor 2|Sorting nexin-6, N-terminally processed|SNX6

58533

Q9UNH7

Human, Mouse, Rat

Sorting nexin 6

SNX6

ELISA, WB, IHC

Stem Cells, Signal Transduction

Immunogen affinity purified

WB: 1:500-1:2000; IHC: 1:20-1:200

≥95% as determined by SDS-PAGE

Liquid

47 kDa

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)