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SNX27 antibody

CAT: 0710-FNab08090Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab08090Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns (3P) ) . May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes.
Synonyms
Sorting nexin-27|SNX27|KIAA0488
Gene ID
81609
UniProt
Q96L92
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Sorting nexin family member 27
Target
SNX27
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
52-60 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

UniProtKB · Q96L92

Sorting nexin-27

SNX27_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q96L92
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SNX27
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q32Q36, Q4AEJ5, Q5VWB0, Q5VWB1, Q5VWB2, Q6IPP6, Q86UB1, Q96D79, Q9H3K8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmEndosomeMembrane

Ligand

Lipid-binding

PTM

Phosphoprotein

Biological process

Protein transportTransport

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