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SMURF1 antibody

CAT: 0710-FNab08046Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab08046Size:100 µg
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Background
E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Plays a role in dendrite formation by melanocytes (PubMed:23999003) .
Synonyms
E3 ubiquitin-protein ligase SMURF1 (hSMURF1) |HECT-type E3 ubiquitin transferase SMURF1|SMAD ubiquitination regulatory factor 1|SMAD-specific E3 ubiquitin-protein ligase 1|SMURF1|KIAA1625
Gene ID
57154
UniProt
Q9HCE7
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
SMAD specific E3 ubiquitin protein ligase 1
Target
SMURF1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Epigenetics, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
83-90 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

UniProtKB · Q9HCE7

E3 ubiquitin-protein ligase SMURF1

SMUF1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9HCE7
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SMURF1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
hSMURF1
EC number
2.3.2.26
Processing
—
Secondary accessions
A4D279, B7ZMB6, B9EGV3, O75853, Q547Q3, Q9UJT8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneCytoplasmMembrane

Biological process

DifferentiationUbl conjugation pathway

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Domain

Repeat

Molecular function

Transferase

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