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SMN1 antibody

CAT: 0710-FNab08033Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab08033Size:100 µg
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Background
The survival of motor neurons (SMN) genes are the disease genes of spinal muscular atrophy (SMA), a common motor neuron degenerative disease. The level of SMN protein correlates with phenotypic severity of SMA. SMA patients lack a functional SMN1 gene, but they possess an intact SMN2 gene, which though nearly identical to SMN1, is only partially functional, because a large majority of SMN2 transcripts lack exon 7, resulting in production of a truncated, less stable SMN protein. This antibody can recognize human, mouse and rat SMN.
Synonyms
Survival motor neuron protein|Component of gems 1|Gemin-1|SMN1|SMN|SMNT
UniProt
Q16637
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
Survival of motor neuron 2, centromeric
Target
SMN1
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, WB, IF
Field of Research
Neuroscience, Metabolism
Purification
Protein A+G purification
Dilution
WB: 1:1000-1:6000; IF: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
38 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
3D2
Tested Applications
ELISA, WB, IF

UniProtKB · Q16637

Survival motor neuron protein

SMN_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q16637
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SMN1, SMN2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A8K0V4, Q13119, Q549U5, Q96J51
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Cellular component

Cell projectionCytoplasmNucleus

Disease

Disease variantNeurodegeneration

Biological process

mRNA processingmRNA splicingNeurogenesis

Molecular function

RNA-binding

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