SMN1 antibody

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SMN1 antibody

CAT:

710-FNab08030

Size:

100 µg

Price:

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For price, please contact [email protected].

Background: This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. While mutations in the telomeric copy are associated with spinal muscular atrophy, mutations in this gene, the centromeric copy, do not lead to disease. This gene may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The full length protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Four transcript variants encoding distinct isoforms have been described.
Synonyms: Survival motor neuron protein|Component of gems 1|Gemin-1|SMN1|SMN|SMNT
Gene ID: 6607
UniProt: Q16637
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: survival of motor neuron 2, centromeric
Target: SMN1
Clonality: Polyclonal
Isotype: IgG
Applications: ELISA, WB, IHC
Field of Research: Neuroscience, Metabolism
Purification: Immunogen affinity purified
Dilution: WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular Weight: 38 kDa
Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Complementary Product Range

Our range of products, including SMN1 antibody, falls within the same field of application and can be used across various research projects. These products are carefully selected for their high performance and reliability, supporting the diverse needs of modern laboratories. Whether for ongoing studies or future experiments, they are designed to help researchers achieve their scientific goals. Here are some related products that may be of interest for similar or future applications:

Each item in our collection, is tested for precision and quality, ensuring dependable solutions for your research. As we continue to incorporate the latest advancements, Gentaur ensures that our product range remains relevant and versatile, providing you with the tools needed for both current and future projects.

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Cat	Name
FNab08030	SMN1 antibody
FNab08031	SMN1 antibody
FNab08032	SMN1 antibody
FNab08033	SMN1 antibody
FNab08034	SMN1(human-Specific) antibody
P5884-03	Recombinant Human SMN1
P0820-03	Recombinant Human SMN1
P0820-02	Recombinant Human SMN1
P0820-01	Recombinant Human SMN1
P5884-02	Recombinant Human SMN1