SLC5A8 antibody

Acts as an electrogenic sodium (Na (+) ) and chloride (Cl-) -dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na (+) :substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na (+) gradient and hence contribute to the maintenance of the energy status and function of neurons.

Sodium-coupled monocarboxylate transporter 1|Apical iodide transporter|Electrogenic sodium monocarboxylate cotransporter|Sodium iodide-related cotransporter|Solute carrier family 5 member 8|SLC5A8|AIT|SMCT|SMCT1

160728

Q8N695

Human, Mouse, Rat

Solute carrier family 5 (iodide transporter), member 8

SLC5A8

ELISA, IF, WB

Signal Transduction, Metabolism

Immunogen affinity purified

WB: 1:500-1:2000; IF: 1:20-1:200

≥95% as determined by SDS-PAGE

Liquid

67 kDa

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)