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SKP1 antibody

CAT: 0710-FNab07897Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab07897Size:100 µg
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Background
This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein (s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.
Synonyms
S-phase kinase-associated protein 1|Cyclin-A/CDK2-associated protein p19 (p19A) |Organ of Corti protein 2 (OCP-2) |Organ of Corti protein II (OCP-II) |RNA polymerase II elongation factor-like protein|SIII|Transcription elongation factor B polypeptide 1-like|p19skp1|SKP1|EMC19|OCP2|SKP1A|TCEB1L
Gene ID
6500
UniProt
P63208
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
S-phase kinase-associated protein 1
Target
SKP1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Cell Division and Proliferation, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
19 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

UniProtKB · P63208

S-phase kinase-associated protein 1

SKP1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P63208
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SKP1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
D3DQ97, D3DQ98, P34991, Q8TAY2
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Host-virus interactionUbl conjugation pathway

PTM

Isopeptide bondPhosphoproteinUbl conjugation

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