SIGLEC7 antibody

CAT: 0710-FNab07862Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0710-FNab07862Size:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3-and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide) . The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase (s) via their SH2 domain (s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro) .

Synonyms

Gene ID

27036

UniProt

Q9Y286

Host

Rabbit

Reactivity

Human

Immunogen

Sialic acid binding Ig-like lectin 7

Target

SIGLEC7

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB, IHC

Field of Research

Neuroscience, Immunology, Signal Transduction

Purification

Immunogen affinity purified

Dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

Purity

≥95% as determined by SDS-PAGE

Form

Liquid

Molecular Weight

75 kDa

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Tested Applications

ELISA, WB, IHC

UniProtKB · Q9Y286

Sialic acid-binding Ig-like lectin 7

SIGL7_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q9Y286
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: SIGLEC7
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: Siglec-7
EC number: —
Processing: Precursor
Secondary accessions: Q9NZQ1, Q9UJ86, Q9UJ87, Q9Y502

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cell adhesion

PTM

Disulfide bondGlycoproteinPhosphoprotein

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

Ligand

Lectin

Cellular component

Membrane

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Alternative Products

Catalog	Name
GTR17881530-01	SIGLEC7 Antibody