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SF3B4 antibody

CAT: 0710-FNab07780Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab07780Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
Synonyms
Splicing factor 3B subunit 4|Pre-mRNA-splicing factor SF3b 49 kDa subunit|Spliceosome-associated protein 49 (SAP 49) |SF3B4|SAP49
Gene ID
10262
UniProt
Q15427
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Splicing factor 3b, subunit 4, 49kDa
Target
SF3B4
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Neuroscience, Metabolism, Epigenetics
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
50 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

UniProtKB · Q15427

Splicing factor 3B subunit 4

SF3B4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q15427
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SF3B4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q5SZ63
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Biological process

mRNA processingmRNA splicing

Cellular component

NucleusSpliceosome

Domain

Repeat

Molecular function

RNA-binding

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