SET antibody

• Background:

  The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT) . This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene.

• Synonyms:

  Protein SET|HLA-DR-associated protein II|Inhibitor of granzyme A-activated DNase (IGAAD) |PHAPII|Phosphatase 2A inhibitor I2PP2A (I-2PP2A) |Template-activating factor I (TAF-I) |SET

• Gene ID:

  6418

• UniProt:

  Q01105

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  SET nuclear oncogene

• Target:

  SET

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IHC

• Field of Research:

  Neuroscience, Cell Division and Proliferation, Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  33 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IHC

• Immunogen Sequence:

  160-290aa