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RWDD3 antibody

CAT: 0710-FNab07540Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab07540Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Isoform 1 and isoform 2 positively regulate the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Isoform 1 and isoform 2 negatively regulate the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Isoform 2 promotes the sumoylation and transcriptional activity of the glucocorticoid receptor NR3C1 and enhances the interaction of SUMO1 and NR3C1 with UBE2I/UBC9. Has no effect on ubiquitination.
Synonyms
RWD domain-containing protein 3|RWD domain-containing sumoylation enhancer (RSUME) |RWDD3|RSUME
Gene ID
25950
UniProt
Q9Y3V2
Host
Rabbit
Reactivity
Human
Immunogen
RWD domain containing 3
Target
RWDD3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC
Field of Research
Cell Division and Proliferation
Purification
Immunogen affinity purified
Dilution
IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC

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