Products for Research Use Only
RegisterLogin

RSPO3 antibody

CAT: 0710-FNab07512Size: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0710-FNab07512Size:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (PubMed:21727895, PubMed:21909076, PubMed:22615920) . Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity) .
Synonyms
R-spondin-3|Protein with TSP type-1 repeat (hPWTSR) |Roof plate-specific spondin-3 (hRspo3) |Thrombospondin type-1 domain-containing protein 2|RSPO3|PWTSR|THSD2
Gene ID
84870
UniProt
Q9BXY4
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
R-spondin 3 homolog
Target
RSPO3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Neuroscience
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:1000; IHC: 1:100-1:400
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
40 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
22-272aa

UniProtKB · Q9BXY4

R-spondin-3

RSPO3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9BXY4
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
RSPO3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B2RC27, Q5VTV4, Q96K87
Protein keywords

Coding sequence diversity

Alternative splicing

PTM

Disulfide bondGlycoprotein

Molecular function

Heparin-binding

Technical term

Proteomics identificationReference proteome

Domain

RepeatSignal

Cellular component

Secreted

Biological process

Sensory transductionWnt signaling pathway

Related Products

CatalogName
P1916-01Recombinant Human RSPO3
EH12013Human RSPO3 (R-spondin-3) ELISA Kit
QT-EH12013Human RSPO3 (R-spondin-3) QuickTest ELISA Kit
FNab07509RSPH3 antibody
FNab07511RSPO2 antibody
Pr23001-01Recombinant Mouse RSPO2
Pr22972-01Recombinant Human RSPO2
Pr22873-01Recombinant Human RSPO1
Pr22261-01Recombinant Mouse RSPO1
P9129-01Recombinant Human RSPH3

Alternative Products

CatalogName
MBS9611479-01RSPO3 Antibody

Popular Products