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RSPO3 antibody

CAT: 0710-FNab07512Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab07512Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (PubMed:21727895, PubMed:21909076, PubMed:22615920) . Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity) .
Synonyms
R-spondin-3|Protein with TSP type-1 repeat (hPWTSR) |Roof plate-specific spondin-3 (hRspo3) |Thrombospondin type-1 domain-containing protein 2|RSPO3|PWTSR|THSD2
Gene ID
84870
UniProt
Q9BXY4
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
R-spondin 3 homolog
Target
RSPO3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Neuroscience
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:1000; IHC: 1:100-1:400
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
40 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
22-272aa

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