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RPL13A antibody

CAT: 0710-FNab07413Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab07413Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA.
Synonyms
Large ribosomal subunit protein uL13|23 kDa highly basic protein|60S ribosomal protein L13a|RPL13A
Gene ID
23521
UniProt
P40429
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Ribosomal protein L13a
Target
RPL13A
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
25-28 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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