RGMA antibody

CAT: 0710-FNab07261Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0710-FNab07261Size:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

Synonyms

Repulsive guidance molecule A|RGM domain family member A|RGMA|RGM

Gene ID

56963

UniProt

Q96B86

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

RGM domain family, member A

Target

RGMA

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB, IP

Field of Research

Neuroscience

Purification

Immunogen affinity purified

Dilution

WB: 1:500-1:2000; IP: 1:200-1:2000

Purity

≥95% as determined by SDS-PAGE

Form

Liquid

Molecular Weight

49 kDa

Shipping Conditions

4°C with ice bag

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Tested Applications

ELISA, WB, IP

UniProtKB · Q96B86

Repulsive guidance molecule A

RGMA_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q96B86
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: RGMA
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: Precursor
Secondary accessions: B2RTW1, B7Z5S8, F5GXQ7, F5GZU6, G3V518, Q0JV97, Q8NC80, Q9H0E6, Q9NPM3

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

PTM

Autocatalytic cleavageDisulfide bondGlycoproteinGPI-anchorLipoprotein

Cellular component

Cell membraneMembrane

Domain

Signal

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