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RBX1 antibody

CAT: 0710-FNab07199Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab07199Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41. In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM.
Synonyms
E3 ubiquitin-protein ligase RBX1|E3 ubiquitin-protein transferase RBX1|Protein ZYP|RING finger protein 75|RING-box protein 1 (Rbx1) |Regulator of cullins 1 (ROC1) |E3 ubiquitin-protein ligase RBX1, N-terminally processed Alternative names: E3 ubiquitin-protein transferase RBX1, N-terminally processed|RBX1|RNF75|ROC1
Gene ID
9978
UniProt
P62877
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Ring-box 1
Target
RBX1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP
Field of Research
Epigenetics, Cell Division and Proliferation, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
12 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IP

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