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RBL2 antibody

CAT: 0710-FNab07157Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab07157Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Synonyms
Retinoblastoma-like protein 2|130 kDa retinoblastoma-associated protein (p130) |Retinoblastoma-related protein 2 (RBR-2) |pRb2|RBL2|RB2
Gene ID
5934
UniProt
Q08999
Host
Rabbit
Reactivity
Human
Immunogen
Retinoblastoma-like 2 (p130)
Target
RBL2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA
Field of Research
Metabolism, Immunology, Cancer, Developmental biology, Cell Division and Proliferation
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
130 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA

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