RAB5A antibody

CAT: 0710-FNab07038Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab07038Size:100 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032) . Contributes to the regulation of filopodia extension (PubMed:14978216) . Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413) . Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity) .
Synonyms
Ras-related protein Rab-5A|RAB5A|RAB5
Gene ID
5868
UniProt
P20339
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
RAB5A, member RAS oncogene family
Target
RAB5A
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, WB, IP,IF
Field of Research
Neuroscience, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IP:1:200-1:2000; IHC: 1:50-1:500; IF: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
24 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, WB, IP, IF

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