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PUM2 antibody

CAT: 0710-FNab06955Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab06955Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187) . Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276) . Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517) . Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517) . Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845) . Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866) . May regulate DCUN1D3 mRNA levels (PubMed:25349211) . May support proliferation and self-renewal of stem cells.
Synonyms
Pumilio homolog 2 (Pumilio-2) |PUM2|KIAA0235|PUMH2
Gene ID
23369
UniProt
Q8TB72
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Pumilio homolog 2 (Drosophila)
Target
PUM2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Stem Cells, Immunology, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
140 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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