PTPRJ antibody

• Background :

  Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.

• Synonyms :

  Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta, R-PTP-eta) |Density-enhanced phosphatase 1 (DEP-1) |HPTP eta|Protein-tyrosine phosphatase receptor type J (R-PTP-J) |PTPRJ|DEP1

• Gene ID :

  5795

• UniProt :

  Q12913

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  Protein tyrosine phosphatase, receptor type, J

• Target :

  PTPRJ

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Applications :

  ELISA, WB

• Field of Research :

  Neuroscience, Immunology, Signal Transduction, Metabolism

• Purification :

  Immunogen affinity purified

• Dilution :

  WB: 1:500-1:2000

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  146-170 kDa

• Shipping Conditions :

  4°C with ice bag

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications :

  ELISA, WB