PSAP antibody

• Background:

  Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46) . Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22) . Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12) . Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.

• Synonyms:

  Prosaposin|Proactivator polypeptide|Saposin-A Alternative names: Protein A|Saposin-B-Val|Saposin-B Alternative names: Cerebroside sulfate activator (CSAct) |Dispersin|Sphingolipid activator protein 1 (SAP-1) |Sulfatide/GM1 activator|Saposin-C Alternative names: A1 activator|Co-beta-glucosidase|Glucosylceramidase activator|Sphingolipid activator protein 2 (SAP-2) |Saposin-D Alternative names: Component C|Protein C|PSAP|GLBA|SAP1

• Gene ID:

  5660

• UniProt:

  P07602

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Prosaposin

• Target:

  PSAP

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IHC

• Field of Research:

  Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  60 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IHC

• Immunogen Sequence:

  311-390aa