PSAP antibody

CAT: 0710-FNab06840Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab06840Size:100 µg
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Background
This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Synonyms
Prosaposin|Proactivator polypeptide|Saposin-A Alternative names: Protein A|Saposin-B-Val|Saposin-B Alternative names: Cerebroside sulfate activator (CSAct) |Dispersin|Sphingolipid activator protein 1 (SAP-1) |Sulfatide/GM1 activator|Saposin-C Alternative names: A1 activator|Co-beta-glucosidase|Glucosylceramidase activator|Sphingolipid activator protein 2 (SAP-2) |Saposin-D Alternative names: Component C|Protein C|PSAP|GLBA|SAP1
Gene ID
5660
UniProt
P07602
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Prosaposin
Target
PSAP
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, WB, IF
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
62 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, WB, IF
Immunogen Sequence
60-310aa

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