PSAP antibody

• Background:

  This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

• Synonyms:

  Prosaposin|Proactivator polypeptide|Saposin-A Alternative names: Protein A|Saposin-B-Val|Saposin-B Alternative names: Cerebroside sulfate activator (CSAct) |Dispersin|Sphingolipid activator protein 1 (SAP-1) |Sulfatide/GM1 activator|Saposin-C Alternative names: A1 activator|Co-beta-glucosidase|Glucosylceramidase activator|Sphingolipid activator protein 2 (SAP-2) |Saposin-D Alternative names: Component C|Protein C|PSAP|GLBA|SAP1

• Gene ID:

  5660

• UniProt:

  P07602

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Prosaposin

• Target:

  PSAP

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, IHC, WB, IF

• Field of Research:

  Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  62 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, IHC, WB, IF

• Immunogen Sequence:

  60-310aa