PQBP1 antibody

CAT: 0710-FNab06743Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0710-FNab06743Size:100 µg

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Background

Probably functions as scaffold protein that is part of numerous complexes and thereby plays a role in pre-mRNA splicing, transcription regulation and neuron development. Required for normal alternative splicing of target pre-mRNA species (PubMed:23512658) . May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit.

Synonyms

Polyglutamine-binding protein 1 (PQBP-1) |38 kDa nuclear protein containing a WW domain (Npw38) |Polyglutamine tract-binding protein 1|PQBP1|NPW38

Gene ID

10084

UniProt

O60828

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Polyglutamine binding protein 1

Target

PQBP1

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB

Field of Research

Metabolism

Purification

Immunogen affinity purified

Dilution

WB: 1:500-1:2000

Purity

≥95% as determined by SDS-PAGE

Form

Liquid

Molecular Weight

38 kDa, 30 kDa

Shipping Conditions

4°C with ice bag

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Tested Applications

ELISA, WB

UniProtKB · O60828

Polyglutamine-binding protein 1

PQBP1_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: O60828
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: PQBP1
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: PQBP-1
EC number: —
Processing: —
Secondary accessions: C9JQA1, Q4VY25, Q4VY26, Q4VY27, Q4VY29, Q4VY30, Q4VY34, Q4VY35, Q4VY36, Q4VY37, Q4VY38, Q9GZP2, Q9GZU4, Q9GZZ4

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

ImmunityInnate immunitymRNA processingmRNA splicingTranscriptionTranscription regulation

Disease

Intellectual disability

Cellular component

Nucleus

PTM

Phosphoprotein

Domain

Repeat

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