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PPP1R8 antibody

CAT: 0710-FNab06709Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab06709Size:100 µg
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Background
This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA.
Synonyms
Nuclear inhibitor of protein phosphatase 1 (NIPP-1) |Protein phosphatase 1 regulatory inhibitor subunit 8|PPP1R8|ARD1|NIPP1
Gene ID
5511
UniProt
Q12972
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Protein phosphatase 1, regulatory (inhibitor) subunit 8
Target
PPP1R8
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, WB, IF
Field of Research
Neuroscience, Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
40 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, WB, IF

UniProtKB · Q12972

Nuclear inhibitor of protein phosphatase 1

PP1R8_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q12972
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PPP1R8
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
NIPP-1
EC number
—
Processing
—
Secondary accessions
Q5TEJ2, Q5TEJ4, Q5TIF2, Q6PKF6, Q9UBH1, Q9UBZ0
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleusSpliceosome

Molecular function

DNA-bindingEndonucleaseHydrolaseNucleaseProtein phosphatase inhibitorRepressorRNA-binding

Ligand

Magnesium

Biological process

mRNA processingmRNA splicingTranscriptionTranscription regulation

PTM

Phosphoprotein

Domain

Repeat

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