PPM1A antibody

• Background:

  Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.

• Synonyms:

  Protein phosphatase 1A|Protein phosphatase 2C isoform alpha (PP2C-alpha) |Protein phosphatase IA|PPM1A|PPPM1A

• Gene ID:

  5494

• UniProt:

  P35813

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform

• Target:

  PPM1A

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB

• Field of Research:

  Signal Transduction, Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:2000

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  42 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB