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PMEPA1 antibody

CAT: 0710-FNab06569Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab06569Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487) . Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514) .
Synonyms
Protein TMEPAI|Prostate transmembrane protein androgen induced 1|Solid tumor-associated 1 protein|Transmembrane prostate androgen-induced protein|PMEPA1|STAG1|TMEPAI
Gene ID
56937
UniProt
Q969W9
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Prostate transmembrane protein, androgen induced 1
Target
PMEPA1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
32 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF

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