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M-PEG11-acid

CAT: 0804-HY-140501-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-140501-01Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
M-PEG11-acid is a non-cleavable 11 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. m-PEG11-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
CAS Number
2280998-74-3
UNSPSC
12352203
Hazard Statement
H302-H315-H319-H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/m-peg11-acid.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O
Molecular Formula
C24H48O13
Molecular Weight
544.63
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Wilfried Braje et al. Macrocyclic mcl-1 inhibitors and methods of use. WO2019035927A1.|[2] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker; PEG Linkers

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