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PIAS2 antibody

CAT: 0710-FNab06429Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab06429Size:100 µg
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Background
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'.
Synonyms
E3 SUMO-protein ligase PIAS2|Androgen receptor-interacting protein 3 (ARIP3) |DAB2-interacting protein (DIP) |E3 SUMO-protein transferase PIAS2|Msx-interacting zinc finger protein (Miz1) |PIAS-NY protein|Protein inhibitor of activated STAT x|Protein inhibitor of activated STAT2|PIAS2|PIASX
Gene ID
9063
UniProt
O75928
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Protein inhibitor of activated STAT, 2
Target
PIAS2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
68 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

UniProtKB · O75928

E3 SUMO-protein ligase PIAS2

PIAS2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O75928
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PIAS2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.2.-
Processing
—
Secondary accessions
O75927, Q96BT5, Q96KE3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Molecular function

DNA-bindingTransferase

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Ligand

Metal-bindingZinc

Cellular component

Nucleus

Biological process

TranscriptionTranscription regulationUbl conjugation pathway

Domain

Zinc-finger

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