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EGLN3 antibody

CAT: 0710-FNab06377Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab06377Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
EGLN3, also named as HPH-1, HIF-PH3, HPH-3 and PHD3, is a cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. It hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. It is a regulator of cardiomyocyte and neuronal apoptosis. EGLN3 can be a prognostic marker for gastric cancer.
Synonyms
Prolyl hydroxylase EGLN3|Egl nine homolog 3|HPH-1|Hypoxia-inducible factor prolyl hydroxylase 3 (HIF-PH3, HIF-prolyl hydroxylase 3, HPH-3) |Prolyl hydroxylase domain-containing protein 3 (PHD3) |EGLN3
Gene ID
112399
UniProt
Q9H6Z9
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Egl nine homolog 3
Target
EGLN3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP
Field of Research
Cardiovascular, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
28-32 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

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