PEX5 antibody
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PEX5 antibody
Background :
The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD) . Alternatively spliced transcript variants encoding different isoforms have been identified.Synonyms :
Peroxisomal targeting signal 1 receptor (PTS1 receptor, PTS1R) |PTS1-BP|Peroxin-5|Peroxisomal C-terminal targeting signal import receptor|Peroxisome receptor 1|PEX5|PXR1Gene ID :
5830UniProt :
P50542Host :
RabbitReactivity :
Human, Mouse, RatImmunogen :
Peroxisomal biogenesis factor 5Target :
PEX5Clonality :
PolyclonalIsotype :
IgGApplications :
ELISA, WB, IHC, IFField of Research :
MetabolismPurification :
Immunogen affinity purifiedDilution :
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200Purity :
≥95% as determined by SDS-PAGEForm :
LiquidMolecular Weight :
70 kDaShipping Conditions :
4°C with ice bagStorage Conditions :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)Tested Applications :
ELISA, WB, IHC, IF
