PER2 antibody

• Background:

  PER2, also named as KIAA0347, is a component of the circadian clock mechanism which is essential for generating circadian rhythms. PER2 is a negative element in the circadian transcriptional loop. PER2 influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. It negatively regulates CLOCK|NPAS2-BMAL1|BMAL2-induced transactivation. Defects in PER2 are a cause of familial advanced sleep-phase syndrome (FASPS) which is characterized by very early sleep onset and offset.

• Synonyms:

  Period circadian protein homolog 2 (hPER2) |Circadian clock protein PERIOD 2|PER2|KIAA0347

• Gene ID:

  5697

• UniProt:

  O15055

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Period homolog 2

• Target:

  PER2

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IP

• Field of Research:

  Neuroscience, Cardiovascular, Metabolism, Signal Transduction

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:2000; IP: 1:200-1:1000

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  136 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IP

• Immunogen Sequence:

  1000-1255aa