CD274 antibody

CD274 antibody

• Background: Programmed cell death ligand 1(CD274, or B7-H1, PD-L1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell, and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. PD-L1 is a 290 aa transmembrane protein with a calculated molecular weight of 33 kDa, the apparent molecular weight has been reported as 45-70 kDa, suggesting probable glycosylation(PMID: 18760278; 16493058).?
• Synonyms: Programmed cell death 1 ligand 1 (PD-L1, PDCD1 ligand 1, Programmed death ligand 1, hPD-L1)|B7 homolog 1 (B7-H1)|CD274|B7H1|PDCD1L1|PDCD1LG1|PDL1
• CAS Number: 9007-83-4
• UniProt: Q9NZQ7
• Host: Mouse
• Reactivity: Human, Mouse, Pig
• Immunogen: CD274 molecule
• Target: CD274
• Clonality: Monoclonal
• Isotype: IgG1
• Clone: 6C11
• Applications: ELISA, WB, IHC,IF
• Field of Research: Cancer, Immunology, Signal Transduction
• Purification: Protein A+G purification
• Dilution: WB: 1:500-1:5000; IHC: 1:100-1:500; IF: 1:50-1:500
• Purity: ≥95% as determined by SDS-PAGE
• Form: Liquid
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)