CD274 antibody

CAT: 0710-FNab06281Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab06281Size:100 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
Programmed cell death ligand 1 (CD274, or B7-H1, PD-L1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell, and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. PD-L1 is a 290 aa transmembrane protein with a calculated molecular weight of 33 kDa, the apparent molecular weight has been reported as 45-70 kDa, suggesting probable glycosylation (PMID: 18760278; 16493058) .?
Synonyms
Programmed cell death 1 ligand 1 (PD-L1, PDCD1 ligand 1, Programmed death ligand 1, hPD-L1) |B7 homolog 1 (B7-H1) |CD274|B7H1|PDCD1L1|PDCD1LG1|PDL1
Gene ID
29126
UniProt
Q9NZQ7
Host
Mouse
Reactivity
Human, Mouse, Pig
Immunogen
CD274 molecule
Target
CD274
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, WB, IHC,IF
Field of Research
Cancer, Immunology, Signal Transduction
Purification
Protein A+G purification
Dilution
WB: 1:500-1:5000; IHC: 1:100-1:500; IF: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
40-50 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
6C11
Tested Applications
ELISA, WB, IHC, IF
Immunogen Sequence
25-241 aa

Related Products

CatalogName
P6613-01Recombinant Mouse Cd274
P6857-01Recombinant Human CD274
P8899-01Recombinant Human CD274
FITC-30287-01FITC Anti-Human CD274/PD-L1 Antibody (9F7)
FITC-30044-01FITC Anti-Human CD274 (29E.2A3)
PE-30044-01PE Anti-Human CD274 (29E.2A3)
APC-30030-01APC Anti-Mouse CD274 (10F.9G2)
PE-30030-01PE Anti-Mouse CD274 (10F.9G2)
APC-30044-01APC Anti-Human CD274 (29E.2A3)
FITC-30030-01FITC Anti-Mouse CD274 (10F.9G2)

Alternative Products

CatalogName
E30AC434CD274 Antibody

Popular Products