PDCD4 antibody

• Background:

  Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity) .

• Synonyms:

  Programmed cell death protein 4|Neoplastic transformation inhibitor protein|Nuclear antigen H731-like|Protein 197/15a|PDCD4|H731

• Gene ID:

  27250

• UniProt:

  Q53EL6

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Programmed cell death 4 (neoplastic transformation inhibitor)

• Target:

  PDCD4

• Clonality:

  Monoclonal

• Isotype:

  IgG1

• Applications:

  ELISA, WB, IHC

• Field of Research:

  Metabolism

• Purification:

  Protein A+G purification

• Dilution:

  WB: 1:1000-1:4000; IHC: 1:20-1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  56 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Clone ID:

  3B7

• Tested Applications:

  ELISA, WB, IHC