PDCD4 antibody

• Background :

  Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity) .

• Synonyms :

  Programmed cell death protein 4|Neoplastic transformation inhibitor protein|Nuclear antigen H731-like|Protein 197/15a|PDCD4|H731

• Gene ID :

  27250

• UniProt :

  Q53EL6

• Host :

  Mouse

• Reactivity :

  Human

• Immunogen :

  Programmed cell death 4 (neoplastic transformation inhibitor)

• Target :

  PDCD4

• Clonality :

  Monoclonal

• Isotype :

  IgG1

• Applications :

  ELISA, WB, IHC

• Field of Research :

  Metabolism

• Purification :

  Protein A+G purification

• Dilution :

  WB: 1:1000-1:4000; IHC: 1:20-1:200

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  56 kDa

• Shipping Conditions :

  4°C with ice bag

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Clone ID :

  3B7

• Tested Applications :

  ELISA, WB, IHC