Products for Research Use Only
RegisterLogin

PBX1 antibody

CAT: 0710-FNab06182Size: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0710-FNab06182Size:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4. Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, it is required for spleen development through a mechanism that involves CDKN2B repression (By similarity) .
Synonyms
Pre-B-cell leukemia transcription factor 1|Homeobox protein PBX1|Homeobox protein PRL|PBX1|PRL
Gene ID
5087
UniProt
P40424
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Pre-B-cell leukemia homeobox 1
Target
PBX1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF, IP
Field of Research
Cancer, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
52 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IF, IP

UniProtKB · P40424

Pre-B-cell leukemia transcription factor 1

PBX1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P40424
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PBX1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B4DSC1, F5H4U9, Q5T488
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDevelopmental proteinDNA-bindingRepressor

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Biological process

DifferentiationSexual differentiationSteroidogenesisTranscriptionTranscription regulation

Disease

Disease variantProto-oncogene

Domain

Homeobox

Cellular component

Nucleus

Related Products

CatalogName
P1437-01Recombinant Human PBX1
FNab06183PBX3 antibody
FNab06184PBX4 antibody
FNab10869PBX2 antibody
P10064-01Recombinant Human PBX3
P1825-01Recombinant Human PBX2
P1441-01Recombinant Human PBX4
FNab11062CA125 antibody (capture antibody)
FNab11060AFP antibody (capture antibody)
FNab11045-01CEA antibody (detection antibody)

Alternative Products

CatalogName
10R-5168PBX1 antibody

Popular Products