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PAX6 antibody

CAT: 0710-FNab06172Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab06172Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity) . Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity) . Isoform 5a appears to function as a molecular switch that specifies target genes.
Synonyms
Paired box protein Pax-6|Aniridia type II protein|Oculorhombin|PAX6|AN2
Gene ID
5080
UniProt
P26367
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Paired box 6
Target
PAX6
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, WB
Field of Research
Neuroscience, Stem Cells, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:300-1:1200; IHC: 1:50-1:500; IF: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
47 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, WB

UniProtKB · P26367

Paired box protein Pax-6

PAX6_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P26367
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PAX6
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q6N006, Q99413
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Molecular function

Developmental proteinDNA-bindingRepressor

Biological process

DifferentiationTranscriptionTranscription regulation

Disease

Disease variantPeters anomaly

Domain

HomeoboxPaired box

Cellular component

Nucleus

PTM

Ubl conjugation

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