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PARP1 antibody

CAT: 0710-FNab06151Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab06151Size:100 µg
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Background
This gene encodes a chromatin-associated enzyme, poly (ADP-ribosyl) transferase, which modifies various nuclear proteins by poly (ADP-ribosyl) ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
Synonyms
Poly [ADP-ribose] polymerase 1 (PARP-1) |ADP-ribosyltransferase diphtheria toxin-like 1 (ARTD1) |DNA ADP-ribosyltransferase PARP1|NAD (+) ADP-ribosyltransferase 1 (ADPRT 1) |Poly[ADP-ribose] synthase 1|Protein poly-ADP-ribosyltransferase PARP1|Poly [ADP-ribose] polymerase 1, processed C-terminus Alternative names: Poly [ADP-ribose] polymerase 1, 89-kDa form|Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) Alternative names: Poly [ADP-ribose] polymerase 1, 24-kDa form|Poly [ADP-ribose] polymerase 1, 28-kDa form|PARP1|ADPRT|PPOL
Gene ID
142
UniProt
P09874
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Poly (ADP-ribose) polymerase 1
Target
PARP1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
115 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF

UniProtKB · P09874

Poly [ADP-ribose] polymerase 1

PARP1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P09874
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PARP1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PARP-1
EC number
2.4.2.30
Processing
—
Secondary accessions
B1ANJ4, Q8IUZ9
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationADP-ribosylationIsopeptide bondPhosphoproteinUbl conjugation

Molecular function

Allosteric enzymeDNA-bindingGlycosyltransferaseNucleotidyltransferaseTransferase

Biological process

ApoptosisDNA damageDNA repairImmunityInnate immunityTranscriptionTranscription regulation

Cellular component

ChromosomeCytoplasmNucleus

Ligand

Metal-bindingNADZinc

Domain

RepeatZinc-finger

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