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F2RL1 antibody

CAT: 0710-FNab06145Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab06145Size:100 µg
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Background
Proteinase-activated receptors (PARs) are G protein-coupled receptors activated through cleavage of their N-termini by mainly serine proteases. The family of PARs include four members: PAR1, PAR2, PAR3 and PAR4. PAR2, also known as F2RL1, is expressed in epithelial cells (e.g., lung, gastrointestinal tract), endothelial cells, smooth muscle cells, fibroblasts, nerves, and some immune and inflammatory cells. PAR2 knockout mice and PAR2 agonists and antagonists have implicated PAR2 as a promising target in inflammatory conditions; respiratory, gastrointestinal, metabolic, cardiovascular, and neurological dysfunction; and cancers. (PMID:23895492)
Synonyms
Proteinase-activated receptor 2 (PAR-2) |Coagulation factor II receptor-like 1|G-protein coupled receptor 11|Thrombin receptor-like 1|Proteinase-activated receptor 2, alternate cleaved 1|Proteinase-activated receptor 2, alternate cleaved 2|F2RL1|GPR11|PAR2
UniProt
P55085
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Coagulation factor II (thrombin) receptor-like 1
Target
F2RL1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
50 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

UniProtKB · P55085

Proteinase-activated receptor 2

PAR2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P55085
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
F2RL1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PAR-2
EC number
—
Processing
Precursor
Secondary accessions
Q13317, Q13346, Q53XJ8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoproteinLipoproteinPalmitatePhosphoproteinUbl conjugation

Molecular function

G protein-coupled receptorReceptorTransducer

Biological process

ImmunityInflammatory responseInnate immunity

Domain

SignalTransmembraneTransmembrane helix

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