PAN2 antibody

• Background:

  Catalytic subunit of the poly (A) -nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly (A) tails of RNA when the poly (A) stretch is bound by poly (A) -binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

• Synonyms:

  PAN2-PAN3 deadenylation complex catalytic subunit PAN2|Inactive ubiquitin carboxyl-terminal hydrolase 52|PAB1P-dependent poly (A) -specific ribonuclease|Poly (A) -nuclease deadenylation complex subunit 2 (PAN deadenylation complex subunit 2) |PAN2|KIAA0710|USP52

• Gene ID:

  9924

• UniProt:

  Q504Q3

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  PAN2 poly (A) specific ribonuclease subunit homolog

• Target:

  PAN2

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IHC

• Field of Research:

  Epigenetics, Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:2000; IHC: 1:20-1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  127 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IHC