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SQSTM1 antibody

CAT: 0710-FNab06086Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab06086Size:100 µg
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Background
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.
Synonyms
Sequestosome-1|EBI3-associated protein of 60 kDa (EBIAP, p60) |Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa|Ubiquitin-binding protein p62|SQSTM1|ORCA|OSIL
Gene ID
8878
UniProt
Q13501
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Sequestosome 1
Target
SQSTM1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Neuroscience, Cardiovascular, Metabolism, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:100; IF: 1:20 - 1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
65 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF
Immunogen Sequence
85-440aa

UniProtKB · Q13501

Sequestosome-1

SQSTM_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q13501
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SQSTM1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A6NFN7, B2R661, B3KUW5, Q13446, Q9BUV7, Q9BVS6, Q9UEU1
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondLipoproteinPalmitatePhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Disease

Amyotrophic lateral sclerosisDisease variantNeurodegeneration

Biological process

ApoptosisAutophagyDifferentiationImmunity

Cellular component

CytoplasmCytoplasmic vesicleEndoplasmic reticulumEndosomeLysosomeNucleus

Ligand

Metal-bindingZinc

Domain

Zinc-finger

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